Chemo-mechanical Characterization of Phase-separated Dentin Adhesives

.................................................................................................................................. iii CONTENTS ................................................................................................................................... vi 1 INTRODUCTION AND LITERATURE REVIEW ............................................................... 1 1.1 Introduction ...................................................................................................................... 1 1.1.1 Clinical Relevance .................................................................................................... 1 1.1.2 Adhesive Function .................................................................................................... 1 1.1.3 Preparation of AdhesiveDentin Interface and Hybrid layer ................................... 2 1.1.4 Phase Separation ....................................................................................................... 3 1.1.5 Degree of Polymerization and Polymerization Kinetics ........................................... 4 1.1.6 Diffusion Behavior and Water Sorption ................................................................... 4 1.1.7 Chemo-Poro-Visco-Elastic Mechanical Properties .................................................. 5 1.2 Significance ...................................................................................................................... 6 1.3 Specific Aims: .................................................................................................................. 7 1.3.1 Characterization of Monomer Properties .................................................................. 8 1.3.2 Characterization of Polymer Properties: ................................................................... 8 1.3.3 Mechanical Modeling: .............................................................................................. 9 1.3.4 Innovation ................................................................................................................. 9 1.3.5 Rationale for specific aim 1: Characterization of Monomer Properties ................. 10 1.3.6 Rationale for specific aim 2: Characterization of Polymer Properties .................. 11 1.3.7 Rationale for specific aim 3: Mechanical Modeling ............................................... 12 1.4 Summary (General): ....................................................................................................... 13 1.5 Relevance: ...................................................................................................................... 13 vii 2 CHARACTERIZATION OF DENTIN ADHESIVE SYSTEM USING A TERNARY PHASE DIAGRAM ...................................................................................................................... 23 2.1 Introduction .................................................................................................................... 23 2.2 Materials and Methods ................................................................................................... 25 2.2.1 Materials and nomenclature .................................................................................... 25 2.2.2 Miscibility Experiment ........................................................................................... 26 2.2.3 Phase Separation Experiment ................................................................................. 26 2.2.4 Calibration of FTIR spectra .................................................................................... 27 2.2.5 Degree of conversion .............................................................................................. 28 2.2.6 Polymerization kinetics ........................................................................................... 29 2.2.7 Chemical composition ............................................................................................ 30 2.2.8 Morphology............................................................................................................. 31 2.3 Results and discussion .................................................................................................... 31 2.3.1 Miscibility testing ................................................................................................... 31 2.3.2 Chemometrics based calibration of FTIR spectra ................................................... 32 2.3.3 Phase composition .................................................................................................. 32 2.3.4 Degree of conversion .............................................................................................. 34 2.3.5 Polymerization kinetics ........................................................................................... 35 2.3.6 Polymer phase composition .................................................................................... 36 2.3.7 Polymer porosity ..................................................................................................... 37 2.4 Conclusions .................................................................................................................... 38